Where the MOA technology BioSēq came from

Built to read biology in orbit. Now reading your ingredient.

From two NASA missions to your ingredientSilent · 0:45 · loops

Why BioSēq

Worm-to-human bio-intelligence

BioSēq — the new language of ingredient biology0:55 · sound on

BioSēq™ provides mechanistic insight into the human-relevant genes and pathways modulated by your bioactive — mapping worm DEGs to their human orthologs and enriched pathways.

In vivo transcriptomics in weeks — not years.

Conserved worm-to-human pathways BioSēq resolves

Insulin / IGFCholinergicMAPK / p38AMPKMyogenesisCa²⁺ signalingWnt / β-cateninmTORAdipogenesisDopaminergicTGF-βToll-like / TIR-1NRF2 / SKN-1HSF-1 / HSP90AutophagySirtuinsMitochondrial

Why C. elegans

Faster, cheaper and ethical microorganism for MOA characterization

Labeled anatomy of the nematode C. elegans, adapted from Corsi et al., Wormbook 2015

~20,000

Protein-coding genes

Same number as humans, with 60–80% orthologs.

1 day = 2.85 yr

Whole-lifecycle in <4 weeks

One worm day maps to ~2.85 human years.

959 cells

Fully transparent body

Every cell observable in real time under a microscope.

4 Nobel Prizes

Proven model

Cell death, RNAi, GFP imaging, microRNA (2024).

Swipe to compare →

Capability	Cell assays	C. elegans (TrueBioactives™)	Rodent studies	Clinical study
Whole living organism	No	Yes	Yes	Yes
Absorption and metabolism included	No	Yes	Yes	Yes
Uses vertebrate animals	No	No	Yes	—
Pathways mapped to human orthologues	Partly	Yes	Yes	—
Speed	Fast	Eight weeks	Slow	Slowest
Cost	Low	Moderate	High	Highest

— not applicable.

How it works

From bioactive exposure to translational insight

Bioactive exposure

Your ingredient at a target dose, dosed to C. elegans on the Infinity Chip.

HT RNA-Seq

Bulk RNA-seq across three technical replicates.

Worm-to-human mapping

Worm DEGs mapped to human orthologs with a homology score.

MOA characterization

Enriched human pathways and candidate health benefits.

Trusted platform

Flown in space. Funded by NASA and the NIH. Peer-reviewed.

The organism-on-chip and in vivo transcriptomics platform behind BioSēq has been validated in orbit under federal funding and documented in the peer-reviewed literature.

NCCIH — National Center for Complementary and Integrative Health

Soni et al. — Spaceflight Induces Strength Decline in Caenorhabditis elegans

Cells, 2023

CBIOMES — C. elegans Biological Investigation on Microbiome Effect in Space

NASA Space Biology investigation

Supplementation with bovine thymus extract improves survival, motility and stress resistance in C. elegans

Experimental Gerontology

See all NemaLife publications →